Publications
Here you can find a list of our most relevant publications regarding biofilms and implant infections.
Margaryan D, Renz N, Bervar M, Zahn R, Onken J, Putzier M, Vajkoczy P, Trampuz A. Spinal implant-associated infections: A prospective multicenter cohort study. Int J Antimicrob Agents. 2020
https://pubmed.ncbi.nlm.nih.gov/32726675/
Li C, Ojeda-Thies C, Xu C, Trampuz A. Meta-analysis in periprosthetic joint infection: a global bibliometric analysis. J Orthop Surg Res. 2020 Jul 10;15(1):251
https://pubmed.ncbi.nlm.nih.gov/32650802/
Morgenstern C, Renz N, Cabric S, Maiolo E, Perka C, Trampuz A. Thermogenic diagnosis of periprosthetic joint infection by microcalorimetry of synovial fluid. BMC Musculoskelet Disord. 2020 Jun 3;21(1):345
https://pubmed.ncbi.nlm.nih.gov/32493292/
Alt V, Rupp M, Langer M, Baumann F, Trampuz A. Can the oncology classification system be used for prosthetic joint infection?: The PJI-TNM system. Bone Joint Res. 2020 May 16;9(2):79-81
https://pubmed.ncbi.nlm.nih.gov/32435459/
Li C, Ojeda-Thies C, Renz N, Margaryan D, Perka C, Trampuz A. The global state of clinical research and trends in periprosthetic joint infection: A bibliometric analysis. Int J Infect Dis. 2020 Jul;96:696-709
https://pubmed.ncbi.nlm.nih.gov/32434084/
Köder K, Hardt S, Gellert MS, Haupenthal J, Renz N, Putzier M, Perka C, Trampuz A. Outcome of spinal implant-associated infections treated with or without biofilm-active antibiotics: results from a 10-year cohort study. Infection. 2020 Aug;48(4):559-568
https://pubmed.ncbi.nlm.nih.gov/32372396/
Onsea J, Wagemans J, Pirnay JP, Di Luca M, Gonzalez-Moreno M, Lavigne R, Trampuz A, Moriarty TF, Metsemakers WJ. Bacteriophage therapy as a treatment strategy for orthopaedic-device-related infections: where do we stand? Eur Cell Mater. 2020 May 5;39:193-210
https://pubmed.ncbi.nlm.nih.gov/32368785/
Tkhilaishvili T, Wang L, Perka C, Trampuz A, Gonzalez Moreno M. Using Bacteriophages as a Trojan Horse to the Killing of Dual-Species Biofilm Formed by Pseudomonas aeruginosa and Methicillin Resistant Staphylococcus aureus. Front Microbiol. 2020 Apr 15;11:695
https://pubmed.ncbi.nlm.nih.gov/32351494/
Conen A, Raabe A, Schaller K, Fux CA, Vajkoczy P, Trampuz A. Management of neurosurgical implant-associated infections. Swiss Med Wkly. 2020 Apr 24;150:w20208.
https://pubmed.ncbi.nlm.nih.gov/32329803/
Sigmund IK, Renz N, Feihl S, Morgenstern C, Cabric S, Trampuz A. Value of multiplex PCR for detection of antimicrobial resistance in samples retrieved from patients with orthopaedic infections. BMC Microbiol. 2020 Apr 14;20(1):88
https://pubmed.ncbi.nlm.nih.gov/32290833/
Karbysheva S, Yermak K, Grigoricheva L, Renz N, Perka C, Trampuz A. Synovial Fluid D-lactate-a novel pathogen-specific biomarker for the diagnosis of periprosthetic joint infection. J Arthroplasty. 2020 Aug;35(8):2223-2229.e2
https://pubmed.ncbi.nlm.nih.gov/32269008/
Karbysheva S, Di Luca M, Butini ME, Winkler T, Schütz M, Trampuz A. Comparison of sonication with chemical biofilm dislodgement methods using chelating and reducing agents: Implications for the microbiological diagnosis of implant associated infection. PLoS One
https://pubmed.ncbi.nlm.nih.gov/32267888/
Tkhilaishvili T, Wang L, Tavanti A, Trampuz A, Di Luca M. Antibacterial Efficacy of Two Commercially Available Bacteriophage Formulations, Staphylococcal Bacteriophage and PYO Bacteriophage, Against Methicillin-Resistant Staphylococcus aureus: Prevention and Eradication of Biofilm Formation and Control of a Systemic Infection of Galleria mellonella Larvae. Front Microbiol. 2020 Feb 7;11:110
https://pubmed.ncbi.nlm.nih.gov/32117136/
Depypere M, Morgenstern M, Kuehl R, Senneville E, Moriarty TF, Obremskey WT, Zimmerli W, Trampuz A, Lagrou K, Metsemakers WJ. Pathogenesis and management of fracture-related infection. Clin Microbiol Infect. 2020 May;26(5):652-653
https://pubmed.ncbi.nlm.nih.gov/32087322/
Gonzalez Moreno M, Butini ME, Maiolo EM, Sessa L, Trampuz A. Antimicrobial activity of bioactive glass S53P4 against representative microorganisms causing osteomyelitis – Real-time assessment by isothermal microcalorimetry. Colloids Surf B Biointerfaces. 2020 May;189:110853
https://pubmed.ncbi.nlm.nih.gov/32058256/
Foster AL, Moriarty TF, Trampuz A, Jaiprakash A, Burch MA, Crawford R, Paterson DL, Metsemakers WJ, Schuetz M, Richards RG. Fracture-related infection: current methods for prevention and treatment. Expert Rev Anti Infect Ther. 2020 Apr;18(4):307-321
https://pubmed.ncbi.nlm.nih.gov/32049563/
Gellert M, Hardt S, Köder K, Renz N, Perka C, Trampuz A. Biofilm-active antibiotic treatment improves the outcome of knee periprosthetic joint infection: Results from a 6-year prospective cohort study. Int J Antimicrob Agents. 2020 Apr;55(4):105904
https://pubmed.ncbi.nlm.nih.gov/31958506/
Sigmund IK, Winkler T, Önder N, Perka C, Renz N, Trampuz A. Complications of Resection Arthroplasty in Two-Stage Revision for the Treatment of Periprosthetic Hip Joint Infection. J Clin Med. 2019 Dec 16;8(12):2224
https://pubmed.ncbi.nlm.nih.gov/31888226/
Renz N, Trebse R, Akgün D, Perka C, Trampuz A. Enterococcal periprosthetic joint infection: clinical and microbiological findings from an 8-year retrospective cohort study. BMC Infect Dis. 2019 Dec 27;19(1):1083
https://pubmed.ncbi.nlm.nih.gov/31881851/
Wang L, Di Luca M, Tkhilaishvili T, Trampuz A, Gonzalez Moreno M. Synergistic Activity of Fosfomycin, Ciprofloxacin, and Gentamicin Against Escherichia coli and Pseudomonas aeruginosa Biofilms. Front Microbiol. 2019 Nov 6;10:2522
https://pubmed.ncbi.nlm.nih.gov/31781056/
Metsemakers WJ, Morgenstern M, Senneville E, Borens O, Govaert GAM, Onsea J, Depypere M, Richards RG, Trampuz A, Verhofstad MHJ, Kates SL, Raschke M, McNally MA, Obremskey WT; Fracture-Related Infection (FRI) group. General treatment principles for fracture-related infection: recommendations from an international expert group. Arch Orthop Trauma Surg. 2020 Aug;140(8):1013-1027
https://pubmed.ncbi.nlm.nih.gov/31659475/
Li C, Renz N, Trampuz A, Ojeda-Thies C. Twenty common errors in the diagnosis and treatment of periprosthetic joint infection. Int Orthop. 2020 Jan;44(1):3-14
https://pubmed.ncbi.nlm.nih.gov/31641803/
Depypere M, Kuehl R, Metsemakers WJ, Senneville E, McNally MA, Obremskey WT, Zimmerli W, Atkins BL, Trampuz A; Fracture-Related Infection (FRI) Consensus Group. Recommendations for Systemic Antimicrobial Therapy in Fracture-Related Infection: A Consensus From an International Expert Group. J Orthop Trauma. 2020 Jan;34(1):30-41
https://pubmed.ncbi.nlm.nih.gov/31567902/
Tkhilaishvili T, Winkler T, Müller M, Perka C, Trampuz A. Bacteriophages as Adjuvant to Antibiotics for the Treatment of Periprosthetic Joint Infection Caused by Multidrug-Resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e00924-19
https://pubmed.ncbi.nlm.nih.gov/31527029/
Metsemakers WJ, Fragomen AT, Moriarty TF, Morgenstern M, Egol KA, Zalavras C, Obremskey WT, Raschke M, McNally MA; Fracture-Related Infection (FRI) consensus group. Evidence-Based Recommendations for Local Antimicrobial Strategies and Dead Space Management in Fracture-Related Infection. J Orthop Trauma. 2020 Jan;34(1):18-29
https://pubmed.ncbi.nlm.nih.gov/31464858/
Depypere M, Morgenstern M, Kuehl R, Senneville E, Moriarty TF, Obremskey WT, Zimmerli W, Trampuz A, Lagrou K, Metsemakers WJ. Pathogenesis and management of fracture-related infection. Clin Microbiol Infect. 2020 May;26(5):572-578
https://pubmed.ncbi.nlm.nih.gov/31446152/
Izakovicova P, Borens O, Trampuz A. Periprosthetic joint infection: current concepts and outlook. EFORT Open Rev. 2019 Jul 29;4(7):482-494
https://pubmed.ncbi.nlm.nih.gov/31423332/
Steinmetz S, Wernly D, Moerenhout K, Trampuz A, Borens O. Infection after fracture fixation. EFORT Open Rev. 2019 Jul 15;4(7):468-475
https://pubmed.ncbi.nlm.nih.gov/31423330/
Czuban M, Wulsten D, Wang L, Di Luca M, Trampuz A. Release of different amphotericin B formulations from PMMA bone cements and their activity against Candida biofilm. Colloids Surf B Biointerfaces. 2019 Nov 1;183:110406
https://pubmed.ncbi.nlm.nih.gov/31401462/
Renz N, Rakow A, Müller M, Perka C, Trampuz A. Long-term antimicrobial suppression prevents treatment failure of streptococcal periprosthetic joint infection. J Infect. 2019 Sep;79(3):236-244
https://pubmed.ncbi.nlm.nih.gov/31310778/
Li C, Ojeda-Thies C, Trampuz A. Culture of periprosthetic tissue in blood culture bottles for diagnosing periprosthetic joint infection. BMC Musculoskelet Disord. 2019 Jun 22;20(1):299
https://pubmed.ncbi.nlm.nih.gov/31228938/
Yermak K, Karbysheva S, Perka C, Trampuz A, Renz N. Performance of synovial fluid D-lactate for the diagnosis of periprosthetic joint infection: A prospective observational study. J Infect. 2019 Aug;79(2):123-129
https://pubmed.ncbi.nlm.nih.gov/31125637/
Gonzalez Moreno M, Wang L, De Masi M, Winkler T, Trampuz A, Di Luca M. In vitro antimicrobial activity against Abiotrophia defectiva and Granulicatella elegans biofilms. J Antimicrob Chemother. 2019 Aug 1;74(8):2261-2268
https://pubmed.ncbi.nlm.nih.gov/31049562/
Karczewski D, Winkler T, Renz N, Trampuz A, Lieb E, Perka C, Müller M. A standardized interdisciplinary algorithm for the treatment of prosthetic joint infections. Bone Joint J. 2019 Feb;101-B(2):132-139
https://pubmed.ncbi.nlm.nih.gov/30700114/
Rakow A, Perka C, Trampuz A, Renz N. Origin and characteristics of haematogenous periprosthetic joint infection. Clin Microbiol Infect. 2019 Jul;25(7):845-850
https://pubmed.ncbi.nlm.nih.gov/30678837/